A gallstone, is a lump of hard material usually range in size from a grain of sand to 3-4 cms. They are formed inside the gallbladder formed as a result of precipitation of cholesterol and bile salts from the bile.
Types of gallstones and causes
Cholesterol stones
Pigment stones
Mixed stones - the most common type. They are comprised of cholesterol and salts.
Cholesterol stones are usually yellow-green and are made primarily of hardened cholesterol. They account for about 80 percent of gallstones. Scientists believe cholesterol stones form when bile contains too much cholesterol, too much bilirubin, or not enough bile salts, or when the gallbladder does not empty as it should for some other reason.
Pigment stones are small, dark stones made of bilirubin. The exact cause is not known. They tend to develop in people who have cirrhosis, biliary tract infections, and hereditary blood disorders such as sickle cell anaemia in which too much bilirubin is formed.
Other causes are related to excess excretion of cholesterol by liver through bile. They include the following
Gender. Women between 20 and 60 years of age are twice as likely to develop gallstones as men.
Obesity. Obesity is a major risk factor for gallstones, especially in women.
Oestrogen. Excess oestrogen from pregnancy, hormone replacement therapy, or birth control pills
Cholesterol-lowering drugs.
Diabetes. People with diabetes generally have high levels of fatty acids called triglycerides.
Rapid weight loss. As the body metabolizes fat during rapid weight loss, it causes the liver to secrete extra cholesterol into bile, which can cause gallstones.
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